Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases.
نویسندگان
چکیده
A novel and label-free fluorescence assay for histone acetyltransferase (HAT) activity was established via in situ generation of a nucleic acid-mimicking CoA-Au(I) coordination polymer (CP). Moreover, the potency of this assay for HAT-targeted drug discovery was proved by screening HAT inhibitors.
منابع مشابه
Unique electrocatalytic activity of a nucleic acid-mimicking coordination polymer for the sensitive detection of coenzyme A and histone acetyltransferase activity.
A nucleic acid-mimicking CoA-Ag(I) coordination polymer (CP) was in situ prepared and its unique electrocatalytic activity to H2O2 reduction was discovered. Based on it, a novel, label-free electrochemical sensor has been developed for the sensitive detection of coenzyme A (CoA) and histone acetyltransferase (HAT) activity.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 21 شماره
صفحات -
تاریخ انتشار 2015